Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Purpose Cisplatin-induced hearing loss (CIHL) is a common late effect after childhood
cancer treatment having profound, lifelong consequences that lower quality of life. The …

The zebrafish is a species of freshwater fish, popular in aquariums and laboratories. Several
advantageous features have facilitated zebrafish to be extensively utilized as a valuable …

Hearing disorders pose significant challenges to individuals experiencing them and their
overall quality of life, emphasizing the critical need for advanced pharmacological …

Background: Cisplatin is an effective chemotherapy agent for a wide variety of solid tumors,
but its use is dose-limited by serious side effects including acute kidney injury (AKI) and …

The platinum (Pt)-containing antitumor drugs including cisplatin (cis-
diamminedichloroplatinum II, cDDP), carboplatin, and oxaliplatin, have been the mainstay of …

The inner ear is one of the most complicated structures that harbor organs for the perception
of sound and balance, which is deep in the temporal bone and challenging to operate …

Cisplatin is a chemotherapy drug that causes permanent hearing loss by injuring cochlear
hair cells. Hair cell mitochondria have emerged as potential mediators of hair cell …

Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by
damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical …

Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …