Animals can navigate vast distances and often display behaviours or activities that indicate a detailed, internal spatial representation of their surrounding environment or a 'cognitive …
Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For instance, the learning of a reward site by rodents requires the development of an over …
D Franjic, M Skarica, S Ma, JI Arellano… - Neuron, 2022 - cell.com
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
In this review, we aim to reappraise the organization of intrinsic and extrinsic networks of the entorhinal cortex with a focus on the concept of parallel cortical connectivity streams. The …
The hippocampal formation is critically involved in learning and memory and contains a large proportion of neurons encoding aspects of the organism's spatial surroundings. In the …
In the dentate gyrus–a key component of spatial memory circuits–granule cells (GCs) are known to be morphologically diverse and to display heterogeneous activity profiles during …
The mammalian hippocampal formation (HF) plays a key role in several higher brain functions, such as spatial coding, learning and memory. Its simple circuit architecture is often …
How the topography of neural circuits relates to their function remains unclear. Although topographic maps exist for sensory and motor variables, they are rarely observed for …
Highlights•We review classical ideas on entorhinal–hippocampal structure and function.•Recent data on cell-type specific entorhinal inputs radically change these …