New fundamentals in hemostasis

HH Versteeg, JWM Heemskerk, M Levi… - Physiological …, 2013 - journals.physiology.org
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Venous thrombosis

AS Wolberg, FR Rosendaal, JI Weitz, IH Jaffer… - Nature reviews Disease …, 2015 - nature.com
Venous thromboembolism (VTE) encompasses deep-vein thrombosis (DVT) and pulmonary
embolism. VTE is the leading cause of lost disability-adjusted life years and the third leading …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

[HTML][HTML] Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

M Germain, DI Chasman, H De Haan, W Tang… - The American Journal of …, 2015 - cell.com
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

[HTML][HTML] Factor v Leiden thrombophilia

JL Kujovich - Genetics in medicine, 2011 - Elsevier
Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to
activated Protein C and an increased risk for venous thromboembolism. Deep venous …

Risk factors for venous thromboembolism

SZ Goldhaber - Journal of the American College of Cardiology, 2010 - jacc.org
Risk factors for venous thromboembolism (VTE) are often modifiable and overlap with risk
factors for coronary artery disease. Encouraging our patients to adopt a heart-healthy …

Cross-ancestry investigation of venous thromboembolism genomic predictors

F Thibord, D Klarin, JA Brody, MH Chen, MG Levin… - Circulation, 2022 - Am Heart Assoc
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …

[HTML][HTML] Genetics of venous thrombosis

FR Rosendaal, PH Reitsma - Journal of Thrombosis and Haemostasis, 2009 - Elsevier
Venous thrombosis (deep vein thrombosis, pulmonary embolism) is a common and serious
disorder, with genetic and acquired risk factors. The genetic risk factors can be subdivided in …

Platelet GPVI (glycoprotein VI) and thrombotic complications in the venous system

G Perrella, M Nagy, SP Watson… - … , and vascular biology, 2021 - Am Heart Assoc
The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Venous thromboembolism: epidemiology and magnitude of the problem

SZ Goldhaber - Best practice & research Clinical haematology, 2012 - Elsevier
Pulmonary embolism is the third most common cardiovascular disease after myocardial
infarction and stroke. The death rate from pulmonary embolism exceeds the death rate from …