The function of the RNA-binding protein hnRNP in cancer metastasis
N Han, W Li, M Zhang - Journal of cancer research and …, 2013 - journals.lww.com
Heterogeneous ribonucleoproteins (hnRNPs) are involved in a variety of key cellular
functions and are most likely involved in different steps of pre-mRNA processing. Over the …
functions and are most likely involved in different steps of pre-mRNA processing. Over the …
Genomic instability and cellular senescence: Lessons from the budding yeast
Aging is a complex biological process that occurs in all living organisms. Aging is initiated by
the gradual accumulation of biomolecular damage in cells leading to the loss of cellular …
the gradual accumulation of biomolecular damage in cells leading to the loss of cellular …
Npl3 stabilizes R‐loops at telomeres to prevent accelerated replicative senescence
Telomere shortening rates must be regulated to prevent premature replicative senescence.
TERRA R‐loops become stabilized at critically short telomeres to promote their elongation …
TERRA R‐loops become stabilized at critically short telomeres to promote their elongation …
RNA recognition by Npl3p reveals U2 snRNA-binding compatible with a chaperone role during splicing
A Moursy, A Cléry, S Gerhardy, KM Betz, S Rao… - Nature …, 2023 - nature.com
The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the
RNA sequence (s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 …
RNA sequence (s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 …
Evolutionary Analysis of the hnRNP Interactomes and Their Functions in Eukaryotes
MJ Nishanth, S Jha - Biochemical Genetics, 2024 - Springer
The heterogeneous nuclear ribonucleoproteins (hnRNPs) are central regulators of several
fundamental biological processes across eukaryotes. hnRNPs have been implicated in …
fundamental biological processes across eukaryotes. hnRNPs have been implicated in …
Yeast Npl3 regulates replicative senescence outside of TERRA R-loop resolution and co-transcriptional processing
JJ Wanat, JJ McCann, M Tingey, J Atkins… - … Nucleotides & Nucleic …, 2024 - Taylor & Francis
Eukaryotic cells without telomerase experience progressively shorter telomeres with each
round of cell division until cell cycle arrest is initiated, leading to replicative senescence …
round of cell division until cell cycle arrest is initiated, leading to replicative senescence …
Comprehensive Synthetic Genetic Array Analysis of Alleles That Interact with Mutation of the Saccharomyces cerevisiae RecQ Helicases Hrq1 and Sgs1
E Sanders, PA Nguyen, CM Rogers… - G3: Genes, Genomes …, 2020 - academic.oup.com
Most eukaryotic genomes encode multiple RecQ family helicases, including five such
enzymes in humans. For many years, the yeast Saccharomyces cerevisiae was considered …
enzymes in humans. For many years, the yeast Saccharomyces cerevisiae was considered …
The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1
CV Colombo, C Trovesi, L Menin… - Nucleic Acids …, 2017 - academic.oup.com
Eukaryotic cells preserve genome integrity upon DNA damage by activating a signaling
network that promotes DNA repair and controls cell cycle progression. One of the most …
network that promotes DNA repair and controls cell cycle progression. One of the most …
[PDF][PDF] Towards a Mechanistic Understanding of R-Loop Regulation and Function at Telomeres
VB Pires - 2023 - repositorio-aberto.up.pt
SUMMARY RNA-DNA hybrids are generated during transcription, DNA replication and DNA
repair, due to base pairing of RNA with DNA. They are crucial intermediates in these …
repair, due to base pairing of RNA with DNA. They are crucial intermediates in these …
The structure of yeast Npl3 bound to RNA reveals a cooperative sequence-specific recognition and an RNA chaperone role in splicing
A Moursy, A Cléry, S Gerhardy, KM Betz, S Rao… - bioRxiv, 2022 - biorxiv.org
The conserved SR-like protein Npl3 promotes splicing of diverse pre-mRNAs. However, the
RNA sequence (s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 …
RNA sequence (s) recognized by the RNA Recognition Motifs (RRM1 & RRM2) of Npl3 …