BACKGROUND Multicellular organisms depend on the precise orchestration of gene expression to direct embryonic development and to maintain tissue homeostasis through …
L Di Croce, K Helin - Nature structural & molecular biology, 2013 - nature.com
Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within …
The Polycomb repressive complex 2 (PRC2) mainly mediates transcriptional repression, and has essential roles in various biological processes including the maintenance of cell …
P Voigt, WW Tee, D Reinberg - Genes & development, 2013 - genesdev.cshlp.org
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. Many …
R Margueron, D Reinberg - Nature, 2011 - nature.com
Polycomb group proteins maintain the gene-expression pattern of different cells that is set during early development by regulating chromatin structure. In mammals, two main …
The Polycomb group (PcG) of proteins defines a subset of factors that physically associate and function to maintain the positional identity of cells from the embryo to adult stages. PcG …
Post-translational modifications of histones by protein methyltransferases (PMTs) and histone demethylases (KDMs) play an important role in the regulation of gene expression …
A Laugesen, K Helin - Cell stem cell, 2014 - cell.com
The chromatin environment is essential for the correct specification and preservation of cell identity through modulation and maintenance of transcription patterns. Many chromatin …