Platinum-based drugs have maintained their preeminent position in cancer treatment
regimens even four decades after the approval of cisplatin. Although these agents have …

Methods are presented that detect three types of aberrations in single-particle cryo-EM data
sets: symmetrical and antisymmetrical optical aberrations and magnification anisotropy …

Here, we describe the third major release of RELION. CPU-based vector acceleration has
been added in addition to GPU support, which provides flexibility in use of resources and …

The encapsulation of anticancer metal-based drugs within a protein nanocage represents a
valuable strategy to improve the efficacy and selectivity of these compounds towards cancer …

Herein, we report on the successful encapsulation into human H-ferritin of two highly
charged Ru (II) polypyridyl complexes,[Ru (phen) 2L′] 2+(Ru1, with L′= 4, 4′-(2, 5, 8, 11 …

The combined use of X-ray crystallography and mass spectrometry represents a valuable
strategy to investigate and characterize protein metalation induced by anticancer metal …

Ferritin stores and releases iron ions in mammals. It is globally important as a drug
nanocarrier. This is because of its unique hollow-spherical structure, desirable stability and …

Decoding the interaction between coordination compounds and proteins is of fundamental
importance in biology, pharmacy, and medicine. In this context, protein–ligand docking …

Ferritin (Ft) is a protein with a peculiar three-dimensional architecture. It is characterized by a
hollow cage structure and is responsible for iron storage and detoxification in almost all …

Due to its intrinsic tumor-targeting attribute, limited immunogenicity, and cage architecture,
ferritin emerges as a highly promising nanocarrier for targeted drug delivery. In the effort to …