Helminths are parasitic worms that have successfully co-evolved with their host immune
system to sustain long-term infections. Their successful parasitism is mainly facilitated by …

Obesity, one of the main causes of metabolic syndrome (MetS), is an increasingly common
health and economic problem worldwide, and one of the major risk factors for developing …

Parasitic nematodes are highly successful pathogens, inflicting disease on humans, animals
and plants. Despite great differences in their life cycles, host preference and transmission …

Chronic asthma is associated with persistent lung inflammation and long-term remodelling
of the airways that have proved refractory to conventional treatments such as steroids …

Parasitic helminths and their isolated secreted products show promise as novel treatments
for allergic and autoimmune conditions in humans. Foremost amongst the secreted products …

ES-62 is a protein secreted by the parasitic worm Acanthocheilonema viteae that is anti-
inflammatory by virtue of covalently attached phosphorylcholine. Previously we have …

Helminths regulate host immune responses to ensure their own long-term survival.
Numerous studies have demonstrated that these helminth-induced regulatory mechanisms …

ES‐62 is a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that
protects against ovalbumin (OVA)‐induced airway hyper‐responsiveness in mice by virtue …

Facile diastereoselective access to functionalized oxazol-5-ones and dihydroimidazoles
was accomplished through base-promoted intramolecular amidolysis and methoxide …

Parasitic infections are among the oldest and most common infections in humans. Host
defense alterations caused by autoimmune diseases or immunosuppressive drugs can …