This manuscript reviews recent advances in deterministic global optimization for Mixed-
Integer Nonlinear Programming (MINLP), as well as Constrained Derivative-Free …

A methodology to improve the efficiency of stochastic methods applied to the optimization of
chemical processes with a large number of equality constraints is presented. The …

A multivariable control strategy is developed to control the polymer molecular weight in
emulsion polymerization processes while maximizing the reaction rate by manipulating the …

Dynamic optimization of the emulsion polymerization of vinyl acetate in a pilot scale stirred-
tank reactor was studied. The objective function was defined in order to minimize the …

Optimization of problems with embedded system of ordinary differential equations (ODEs) is
challenging and the difficulty is amplified due to the presence of nonconvexity. In this article …

Advances in metabolic engineering have enabled bioprocess optimization at the genetic
level. Large-scale systematic models are now available at a genome level for many …

Obtaining guaranteed lower bounds for problems with unknown algebraic form has been a
major challenge in derivative-free optimization. In this work, we present a deterministic …

Industrial scale continuous stirred tank reactor (CSTR) for production and grade transitions
of poly vinyl acetate (PVAc) at the different reactor sizes was investigated. Such reactor is …

This chapter presents an overview of applications of metaheuristics to solve different real-
world chemical process engineering problems over the last 30 years. The first part of this …

Monitoring of polymerization variables is necessary to fully implement advanced closedloop
control strategies and to ensure the consistent, safe and optimal production of polymeric …