Mortality impact of achieving WHO cervical cancer elimination targets: a comparative modelling analysis in 78 low-income and lower-middle-income countries

K Canfell, JJ Kim, M Brisson, A Keane, KT Simms… - The Lancet, 2020 - thelancet.com
Background WHO is developing a global strategy towards eliminating cervical cancer as a
public health problem, which proposes an elimination threshold of four cases per 100 000 …

Harnessing progress in radiotherapy for global cancer control

DA Jaffray, F Knaul, M Baumann, M Gospodarowicz - Nature Cancer, 2023 - nature.com
The pace of technological innovation over the past three decades has transformed the field
of radiotherapy into one of the most technologically intense disciplines in medicine …

Updates in the treatment of vaginal cancer

A Jhingran - International Journal of Gynecologic Cancer, 2022 - ijgc.bmj.com
Vaginal cancer is a rare cancer. A lot of the data used in the treatment of this cancer are
extrapolated from cervical cancer data. Radiation therapy plays a significant role in the …

[HTML][HTML] Economic impact of avoidable cancer deaths caused by diagnostic delay during the COVID-19 pandemic: a national population-based modelling study in …

A Gheorghe, C Maringe, J Spice… - European Journal of …, 2021 - Elsevier
Introduction Delays in cancer diagnosis arose from the commencement of non-
pharmaceutical interventions (NPI) introduced in the UK in March 2020 in response to the …

Incidence, treatment and outcomes of cervical cancer in low-and middle-income countries

U Mahantshetty, G Lavanya, S Grover, CA Akinfenwa… - Clinical Oncology, 2021 - Elsevier
Cervical cancer is one of the most common cancers in developing nations. It has had a
tremendous impact on the lifetime of millions of women over the last century and continues …

Glutaminase inhibitors induce thiol-mediated oxidative stress and radiosensitization in treatment-resistant cervical cancers

R Rashmi, K Jayachandran, J Zhang, V Menon… - Molecular cancer …, 2020 - AACR
The purpose of this study was to determine if radiation (RT)-resistant cervical cancers are
dependent upon glutamine metabolism driven by activation of the PI3K pathway and test …

Definitive radiotherapy with image-guided adaptive brachytherapy for primary vaginal cancer

H Westerveld, N Nesvacil, L Fokdal, C Chargari… - The Lancet …, 2020 - thelancet.com
Primary vaginal cancer is a rare cancer and clinical evidence to support recommendations
on its optimal management is insufficient. Because primary vaginal cancer resembles …

Global application of National Comprehensive Cancer Network resource-stratified guidelines for systemic treatment of colon cancer: a population-based, customisable …

BE Wilson, CM Booth, R Sullivan, A Aggarwal… - The Lancet …, 2023 - thelancet.com
Summary Background Resource-stratified guidelines (RSGs) can inform systemic treatment
decisions in the face of limited resources. The objective of this study was to develop a …

Is clinical research serving the needs of the global cancer burden? An analysis of contemporary global radiation therapy randomized controlled trials

J Dodkins, WM Hopman, JC Wells, Y Lievens… - International Journal of …, 2022 - Elsevier
Purpose Randomized controlled trials (RCTs) are the cornerstone of delivering sustained
improvements in cancer outcome. To inform radiation therapy research policy and …

LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6high cervical cancer stem cells

Q Feng, S Li, HM Ma, WT Yang, PS Zheng - Oncogene, 2021 - nature.com
The leucine-rich repeat-containing G-protein-coupled receptor 6 (LGR6) is considered to be
a stem cell marker in many normal tissues and promotes tissue development, regeneration …