Ischaemic stroke is a leading cause of disability and death for which no acute treatments
exist beyond recanalization. The development of novel therapies has been repeatedly …

Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was
first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves …

Astrocytes are active partners in neural information processing [1, 2]. However, the roles of
astrocytes in regulating behavior remain unclear [3, 4]. Because astrocytes have persistent …

Astrocyte-neuron interactions protect neurons from iron-mediated toxicity. As dopamine can
be metabolized to reactive quinones, dopaminergic neurons are susceptible to oxidative …

Circadian disruption has become more prevalent in society due to the increase in shift work,
sleep disruption, blue light exposure, and travel via different time zones. The circadian …

A substantial body of research now implicates the circadian clock in the regulation of an
array of diverse biological processes including glial function, metabolism, peripheral …

Sleep is a vital and evolutionarily conserved process, critical to daily functioning and
homeostatic balance. Losing sleep is inherently stressful and leads to numerous detrimental …

Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …

Circadian clocks sustain daily oscillations in gene expression, physiology, and behavior,
relying on transcription–translation feedback loops of clock genes for rhythm generation …

The circadian clock governs biological timekeeping on a systemic level, helping to regulate
and maintain physiological processes, including endocrine and metabolic pathways with a …