Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for
the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with …

Neutrophils are essential to the homeostatic mission of safeguarding host tissues,
responding rapidly and diversely to breaches of the host's barriers to infection, and returning …

Systemic autoimmune diseases are a group of disorders characterized by a failure in self-
tolerance to a wide variety of autoantigens. In genetically predisposed individuals, these …

Antineutrophil cytoplasmic autoantibodies (ANCAs) are the probable cause of a distinct form
of vasculitis that can be accompanied by necrotizing granulomatosis. Clinical and …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

Rheumatic diseases are a collection of disorders defined by the presence of inflammation
and destruction of joints and internal organs. A common feature of these diseases is the …

Vasculitis is inflammation of vessel walls. It has many causes, although they result in only a
few histologic patterns of vascular inflammation. Vessels of any type in any organ can be …

Anti-neutrophil cytoplasmic autoantibodies (ANCA) are in the circulation of most patients
with pauci-immune necrotizing vasculitis and pauci-immune crescentic glomerulonephritis …

In order to obtain a novel binding protein against a chosen target, DNA molecules, each
encoding a protein comprising one of a family of similar potential binding domains and a …

Polymorphonuclear neutrophils form a primary line of defense against bacterial infections
using complementary oxidative and non-oxidative pathways to destroy phagocytized …