Lipid peroxidation produces a diverse mixture of saturated and unsaturated aldehydes in exhaled breath that can serve as biomarkers of lung cancer—a review

SR Sutaria, SS Gori, JD Morris, Z Xie, XA Fu, MH Nantz - Metabolites, 2022 - mdpi.com
The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that
creates a complex mixture of volatile organic compounds including aldehydes. Elevated …

Analysis of a broad range of carbonyl metabolites in exhaled breath by UHPLC-MS

Z Xie, JD Morris, SJ Mattingly, SR Sutaria… - Analytical …, 2023 - ACS Publications
Analysis of volatile organic compounds (VOCs) in exhaled breath (EB) has shown great
potential for disease detection including lung cancer, infectious respiratory diseases, and …

Design and rationale of the biomarker center of the Household Air Pollution Intervention Network (HAPIN) trial

DB Barr, N Puttaswamy, LM Jaacks… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Biomarkers of exposure, susceptibility, and effect are fundamental for
understanding environmental exposures, mechanistic pathways of effect, and monitoring …

2, 4-dinitrophenylhydrazine capturing combined with mass defect filtering strategy to identify aliphatic aldehydes in biological samples

SY Wang, H Liu, JH Zhu, SS Zhou, JD Xu… - … of Chromatography A, 2022 - Elsevier
Aliphatic aldehydes are toxic substances that correlate with the onset of many diseases.
However, up to date, the methods to identify aliphatic aldehydes in biological samples are …

Method validation and characterization of the associated uncertainty for malondialdehyde quantification in exhaled breath condensate

M Hemmendinger, JJ Sauvain, NB Hopf, P Wild… - Antioxidants, 2021 - mdpi.com
There are several methods for quantifying malondialdehyde (MDA), an oxidative stress
biomarker, in exhaled breath condensate (EBC). However, due to the very diluted nature of …

[HTML][HTML] Rapid and reliable quantification of urinary malondialdehyde by HILIC-MS/MS: A derivatization-free breakthrough approach

G Chango, D García-Gómez, CG Pinto… - Analytica Chimica …, 2024 - Elsevier
Background The development of fast analytical methods is crucial for the research,
discovery, and confirmation of crucial biomarkers. Furthermore, the implementation of fast …

Design and analysis of exhaled breath condenser system for rapid collection of breath condensate

R Ilhamsyah, JMD Dimandja… - Journal of The …, 2021 - iopscience.iop.org
Breath analysis has attracted a lot of interest for noninvasive health diagnostics method by
detecting disease biomarkers. However, the exhaled breath collection process remains a …

Sample preparation approaches for qualitative and quantitative analysis of lipid-derived electrophile modified proteomes by mass spectrometry

W Yuan, J Wang, Y Zhang, H Lu - Molecular Omics, 2020 - pubs.rsc.org
Lipid-derived electrophile (LDE) modifications, which are covalent modifications of proteins
by endogenous LDEs, are essential types of protein posttranslational modifications. LDE …

Novel breath collection techniques for detection of COVID-19.

J Morris - 2023 - ir.library.louisville.edu
Abstract Volatile Organic Compounds (VOC) generated endogenously in the human body
can be used to detect diseases that induce oxidative stress and inflammation. Breath …

Alpha, beta-unsaturated aldehydes: the underrepresented markers of disease.

S Sutaria - 2022 - ir.library.louisville.edu
The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that
creates a complex mixture of volatile organic compounds including aldehydes. Elevated …