Aldosterone is a steroid hormone synthesized in and secreted from the outer layer of the
adrenal cortex, the zona glomerulosa. Aldosterone is responsible for regulating sodium …

The purpose of this article is to review fundamentals in adrenal gland histophysiology. Key
findings regarding the important signaling pathways involved in the regulation of …

Thioredoxin-interacting protein (Txnip) is a metabolic regulator, which modulates insulin
sensitivity and likely plays a role in type 2 diabetes. We studied the regulation of Txnip in …

The adrenal gland controls a plethora of crucial physiological functions, and dysfunction is
associated with severe morbidity. Because of the vital importance of appropriate adrenal …

Context: Primary pigmented nodular adrenocortical disease, associated with Carney
complex, is caused by mutations in PRKAR1A (mt-PRKAR1A), a gene that codes for the …

Pro-opiomelanocortin (POMC) is a polypeptide precursor known to yield biologically active
peptides related to a range of functions. These active peptides include the …

ACTH is the hormone known to control adrenal cortex function and maintenance in the intact
animal but, in culture, it inhibits proliferation of adrenocortical cells from different mammalian …

The molecular mechanisms underlying adrenal and thyroid neuroendocrine tumors,
including their tumorigenesis, progression, and metastasis, involve unique pathways …

MicroRNAs (miRNAs) are an abundant class of small RNAs that regulate expressions of
most genes. miRNAs play important roles in the pituitary, the “master” endocrine organ …

The adrenal gland influences a multitude of processes during stress response, but also
potently affects the immune system, glucose metabolism, electrolyte or water homeostasis …