Finding strategies against the development of antibiotic resistance is a major global
challenge for the life sciences community and for public health. The past decades have seen …

Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

With advances in sequencing technology, uncharacterized proteins and domains of
unknown function (DUFs) are rapidly accumulating in sequence databases and offer an …

Azole compounds are an important class of nitrogen heterocycles with electron-rich
property. This special structure endows azole-based derivatives easily bind with the …

Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Thiopeptides, or thiazolyl peptides, are a relatively new family of antibiotics that already
counts with more than one hundred different entities. Although they are mainly isolated from …

This Review is devoted to the chemistry of macrocyclic peptides having heterocyclic
fragments in their structure. These motifs are present in many natural products and synthetic …

Clostridium difficile (C. difficile) is a Gram positive, anaerobic bacterium that infects the
lumen of the large intestine and produces toxins. This results in a range of syndromes from …

The recent development of thiopeptide analogues of antibiotics has allowed some of the
limitations inherent to these naturally occurring substances to be overcome. Chemical …

Molecules isolated from natural sources including bacteria, fungi, and plants are a long-
standing source of therapeutics that continue to add to our medicinal arsenal today. Despite …