During pregnancy, semiallogeneic fetal extravillous trophoblasts (EVT) invade the uterine
mucosa without being rejected by the maternal immune system. Several mechanisms were …

HLA-G is a molecule that was first known to confer protection to the fetus from destruction by
the immune system of its mother, thus critically contributing to fetal–maternal tolerance. The …

Phenotypic heterogeneity has been observed in most malignancies, which represents a
considerable challenge for tumor therapy. In recent decades, the biological function and …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

Current therapies against cancer utilize the patient's immune system for tumor eradication.
However, tumor cells can evade immune surveillance of CD8+ T and/or natural killer (NK) …

MicroRNAs (miRNAs) are small noncoding RNAs that repress the translation of their target
genes. It has previously been shown that a target's availability to miRNA can be affected by …

BACKGROUND Although the immune system intuitively must have an important role in
embryo implantation and in the achievement of a pregnancy, the molecular details have for …

Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex
class I (MHC I) molecule, and under physiological conditions, its expression is strictly …

Background HLA-G is an immune checkpoint molecule. Since a differential molecule
expression has been reported even for healthy individuals, many studies have focused on …

HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents
substantial nucleotide variability in its regulatory regions. However, it encodes a limited …