Type 2 diabetes mellitus is a chronic metabolic disorder that results from defects in both
insulin secretion and insulin action. An elevated rate of basal hepatic glucose production in …

The properties and roles of ATP-sensitive (KATP) and inwardly rectifying (KIR) potassium
channels are reviewed. Potassium channels regulate the membrane potential of smooth …

Stevioside is present in the plant Stevia rebaudiana Bertoni (SrB). Extracts of SrB have been
used for the treatment of diabetes in, for example, Brazil, although a positive effect on …

OBJECTIVE. Because a pseudonormal pattern of ventricular filling has never been
considered in studies that reported a prevalence of left ventricular diastolic dysfunction …

OBJECTIVE—Metformin is considered contraindicated in patients with heart failure because
of concerns over lactic acidosis, despite increasing evidence of potential benefit. The aim of …

SIXTEEN million individuals in the United States with type 2 diabetes mellitus and an
additional 30–40 million with impaired glucose tolerance result in health care costs …

OBJECTIVE Type 2 diabetes is a slowly progressive disease, in which the gradual
deterioration of glucose tolerance is associated with the progressive decrease in β-cell …

OBJECTIVE—The aim of this study was to examine the relationship between use of
metformin and sulfonylurea and mortality in new users of these agents. RESEARCH …

Sulphonylureas have been used for over 50 years to enhance insulin secretion in patients
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …

Aims/hypothesis The aim of this study was to evaluate the risk of adverse cardiovascular
outcomes in patients with type 2 diabetes newly treated with sulfonylureas and metformin …