Imaging hypoxia to improve radiotherapy outcome

MR Horsman, LS Mortensen, JB Petersen… - Nature reviews Clinical …, 2012 - nature.com
Reduced oxygen levels (hypoxia) is one of the most important factors influencing clinical
outcome after radiotherapy. This is primarily because hypoxic cells are resistant to radiation …

Radiation-induced bystander effects—implications for cancer

CB Seymour, C Mothersill - Nature Reviews Cancer, 2004 - nature.com
The term radiation-induced bystander effects describes a situation where cells that have not
been directly exposed to ionizing radiation behave as though they have been exposed: they …

Hypoxia and Glucose Metabolism in Malignant Tumors: Evaluation by [18F]Fluoromisonidazole and [18F]Fluorodeoxyglucose Positron Emission Tomography …

JG Rajendran, DA Mankoff, F O'Sullivan… - Clinical cancer …, 2004 - AACR
Purpose: The aim of this study is to compare glucose metabolism and hypoxia in four
different tumor types using positron emission tomography (PET). 18F-labeled …

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

RE Airley, A Mobasheri - Chemotherapy, 2007 - karger.com
Cancer cells require a steady source of metabolic energy in order to continue their
uncontrolled growth and proliferation. Accelerated glycolysis is one of the biochemical …

Carbonic anhydrase 9 as an endogenous marker for hypoxic cells in cervical cancer

PL Olive, C Aquino-Parsons, SH MacPhail, SY Liao… - Cancer research, 2001 - AACR
The presence of radiation-resistant hypoxic cells in some solid tumors is known to predict for
relapse after radiotherapy. Use of an endogenous marker of hypoxia would be a convenient …

A kinetic model for dynamic [18F]-Fmiso PET data to analyse tumour hypoxia

D Thorwarth, SM Eschmann, F Paulsen… - Physics in Medicine & …, 2005 - iopscience.iop.org
A method is presented to identify and quantify hypoxia in human head-and-neck tumours
based on dynamic [18 F]-Fmiso PET patient data, using a model for the tracer transport. A …

Kinetic analysis of dynamic 18F-fluoromisonidazole PET correlates with radiation treatment outcome in head-and-neck cancer

D Thorwarth, SM Eschmann, J Scheiderbauer… - BMC cancer, 2005 - Springer
Background Hypoxia compromises local control in patients with head-and-neck cancer
(HNC). In order to determine the value of [18 F]-fluoromisonidazole (Fmiso) with regard to …

Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxia

A Daşu, I Toma-Daşu, M Karlsson - Physics in Medicine & …, 2003 - iopscience.iop.org
The tumour microenvironment is considered to be responsible for the outcome of cancer
treatment and therefore it is extremely important to characterize and quantify it …

Measurements of hypoxia using pimonidazole and polarographic oxygen-sensitive electrodes in human cervix carcinomas

M Nordsmark, J Loncaster, C Aquino-Parsons… - Radiotherapy and …, 2003 - Elsevier
Background and purpose: The measurement of tumour oxygenation using Eppendorf
oxygen-sensitive needle electrodes can provide prognostic information but the method is …

Quantifying transient hypoxia in human tumor xenografts by flow cytometry

KL Bennewith, RE Durand - Cancer Research, 2004 - AACR
Transient hypoxia is a poorly understood and potentially important factor that may limit tumor
response to various forms of therapy. We assessed transient hypoxia on a global scale in …