Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …

As a result of metabolic reprogramming, cancer cells display high rates of glycolysis,
causing an excess production of lactate along with an increase in extracellular acidity …

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Although cancer is a diverse set of diseases, cancer cells share a number of adaptive
hallmarks. Dysregulated pH is emerging as a hallmark of cancer because cancers show …

Short-chain fatty acids (SCFA; acetate, propionate, and butyrate) are generated in colon by
bacterial fermentation of dietary fiber. Though diffusion in protonated form is a significant …

Abstract Monocarboxylate transporter (MCT) isoforms 1–4 catalyze the proton‐linked
transport of monocarboxylates such as l‐lactate across the plasma membrane, whereas …

High rate of glycolysis is a metabolic hallmark of cancer. While anaerobic glycolysis
promotes energy production under hypoxia, aerobic glycolysis, the Warburg effect, offers a …

Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in
metabolism and must be transported across both the plasma membrane and mitochondrial …