Arsenic is a trace element and a metalloid which is prominently known as an environmental
hazard. At present, rising health apprehensions are linked to emanating from a wide array of …

A driving force of the cell cycle is the activation of cyclin-dependent kinases (CDKs), the
activities of which are controlled by the ubiquitin-mediated proteolysis of key regulators such …

The current literature is devoid of a clearcut definition of mitotic catastrophe, a type of cell
death that occurs during mitosis. Here, we propose that mitotic catastrophe results from a …

Abstract Tumor-Associated Macrophages (TAM) represent the major inflammatory
component of the stroma of many tumors, able to affect different aspects of the neoplastic …

Arsenic is a toxic heavy metal vastly dispersed all over the earth crust. It manifests several
major adverse health issues to millions of arsenic exposed populations. Arsenic is …

Aurora kinase A (also called STK15 and BTAK) is overexpressed in many human cancers.
Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome …

Errors in mitosis can provide a source of the genomic instability that is typically associated
with tumorigenesis. Many mitotic regulators are aberrantly expressed in tumour cells. These …

Recent findings employing the mdx mouse model for Duchenne muscular dystrophy (DMD)
have revealed that muscle satellite stem cells play a direct role in contributing to disease …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Recent advances in high-throughput sequencing technologies and data science have
facilitated the development of precision medicine to treat cancer patients. Synthetic lethality …