Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known
for its sensitivity to pungent vanilloid compound (ie capsaicin) and noxious stimuli, including …

Transient receptor potential vanilloid 1 (TRPV1) is a calcium-permeable ion channel best
known for its ability to be gated by the pungent constituent of red chili pepper, capsaicin, and …

Climate change is considered the greatest threat to global health. Greenhouse gases as
well as global surface temperatures have increased causing more frequent and intense heat …

Aging is usually considered a key risk factor associated with multiple diseases, such as
neurodegenerative diseases, cardiovascular diseases and cancer. Furthermore, the burden …

Current management of severe asthma relying either on guidelines (bulk approach) or on
disease phenotypes (stratified approach) did not improve the burden of the disease. Several …

TRPV1 has been originally cloned as the heat and capsaicin receptor implicated in acute
pain signalling, while further research has shifted the focus to its importance in chronic pain …

Background Dry eye disease (DED) is a multifactorial disease of the ocular surface
accompanied by neurosensory abnormalities. Here, we evaluated the effectiveness of …

Airway epithelium is the first body surface to contact inhaled irritants and report danger.
Here, we report how epithelial cells recognize and respond to aeroallergen alkaline …

MicroRNAs (miRNAs) are small yet versatile gene tuners that regulate a variety of cellular
processes, including cell growth and proliferation. The aim of this study was to explore how …