High-risk human papillomavirus oncogenic E6/E7 mRNAs splicing regulation

Y Zheng, X Li, Y Jiao, C Wu - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
High-risk human papillomavirus infection may develop into a persistent infection that is
highly related to the progression of various cancers, including cervical cancer and head and …

Roles of RNA methylations in cancer progression, autophagy, and anticancer drug resistance

H Jo, K Shim, D Jeoung - International Journal of Molecular Sciences, 2023 - mdpi.com
RNA methylations play critical roles in RNA processes, including RNA splicing, nuclear
export, nonsense-mediated RNA decay, and translation. Regulators of RNA methylations …

A novel HPV16 splicing enhancer critical for viral oncogene expression and cell immortalization

J Jönsson, L Wang, N Kajitani… - Nucleic Acids …, 2024 - academic.oup.com
High-risk carcinogenic human papillomaviruses (HPVs), eg HPV16, express the E6 and E7
oncogenes from two mRNAs that are generated in a mutually exclusive manner by splicing …

m6A‐Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia

Z Wu, X Zuo, W Zhang, Y Li, R Gui, J Leng… - Advanced …, 2023 - Wiley Online Library
Chronic lymphocytic leukemia (CLL) is a hematological malignancy with high metabolic
heterogeneity. N6‐methyladenosine (m6A) modification plays an important role in …

Alternative splicing in the genome of HPV and its regulation

Y Wang, F Chen, W Qu, Y Gong, Y Wang… - Frontiers in Cellular …, 2024 - frontiersin.org
Persistent infection with high-risk human papillomavirus (HR-HPV) is the main cause of
cervical cancer. These chronic infections are characterized by high expression of the HPV …

Virus usurps alternative splicing to clear the decks for infection

R Li, S Gao, H Chen, X Zhang, X Yang, J Zhao, Z Wang - Virology Journal, 2023 - Springer
Since invasion, there will be a tug-of-war between host and virus to scramble cellular
resources, for either restraining or facilitating infection. Alternative splicing (AS) is a …

[HTML][HTML] DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease

Y Yang, S Ren, J Xue, W Dong, W He, J Luo… - Journal of Advanced …, 2024 - Elsevier
Introduction Diabetic kidney disease (DKD) has become the primary cause of chronic renal
failure in China, and renal tubulointerstitial fibrosis plays a central role in DKD progression …

MACC1 enhances an oncogenic RNA splicing of IRAK1 through interacting with HNRNPH1 in lung adenocarcinoma

S Wang, Z Li, C Chen, T Guo, S Zhao… - Journal of Cellular …, 2024 - Wiley Online Library
Dysregulation of alternative pre‐mRNA splicing plays a critical role in the progression of
cancers, yet the underlying molecular mechanisms remain largely unknown. It is reported …

HPV and RNA Binding Proteins: What We Know and What Remains to Be Discovered

SV Graham - Viruses, 2024 - mdpi.com
Papillomavirus gene regulation is largely post-transcriptional due to overlapping open
reading frames and the use of alternative polyadenylation and alternative splicing to …

Diverse roles of heterogeneous nuclear ribonucleoproteins in viral life cycle

K Bhattarai, M Holcik - Frontiers in Virology, 2022 - frontiersin.org
Understanding the host-virus interactions helps to decipher the viral replication strategies
and pathogenesis. Viruses have limited genetic content and rely significantly on their host …