Machine learning prediction of oncology drug targets based on protein and network properties

Z Dezső, M Ceccarelli - BMC bioinformatics, 2020 - Springer
Background The selection and prioritization of drug targets is a central problem in drug
discovery. Computational approaches can leverage the growing number of large-scale …

Predicting protein targets for drug-like compounds using transcriptomics

NA Pabon, Y Xia, SK Estabrooks, Z Ye… - PLoS computational …, 2018 - journals.plos.org
An expanded chemical space is essential for improved identification of small molecules for
emerging therapeutic targets. However, the identification of targets for novel compounds is …

GWAS and beyond: using omics approaches to interpret SNP Associations

HH Chen, LE Petty, W Bush, AC Naj… - Current genetic medicine …, 2019 - Springer
Abstract Purpose of Review Neurodegenerative diseases, neuropsychiatric disorders, and
related traits have highly complex etiologies but are also highly heritable; identifying the …