Since the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak
emerged, countless efforts are being made worldwide to understand the molecular …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Fibrinogen conversion into insoluble fibrin and the formation of a stable clot is the final step
of the coagulation cascade. Fibrin clot porosity and its susceptibility to plasmin-mediated …

In patients with diabetes, metabolic disorders disturb the physiological balance of
coagulation and fibrinolysis, leading to a prothrombotic state characterized by platelet …

Objective: Post-translational modifications of fibrinogen influence the occurrence and
progression of thrombotic diseases. In this systematic review, we assessed the current …

Trauma is responsible for 1 in 10 deaths worldwide and is the leading cause of death of
people less than 45 years old. 1 The two most common causes of death in trauma victims …

Massive trauma remains a leading cause of death and a global public health burden. Post-
traumatic coagulopathy may be present even before the onset of resuscitation, and …

Preeclampsia (PE) is a common obstetric disease characterized by hypertension,
proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health …

Acentury ago, Walter B. Cannon, after studying battlefield casualties, concluded “… shock is
a lack of homeostasis and without homeostasis the patient does not survive. 1 This …

Fibrinogen is a key component of the inflammation and clotting pathways and an
established risk factor for cardiovascular disease. Flavonoids have been shown to be …