CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Cystic fibrosis transmembrane conductance regulator (CFTR), a Cl−-selective ion channel,
is a prototypic member of the ATP-binding cassette transporter superfamily that is expressed …

Exocytic and endocytic compartments each have their own unique luminal ion and pH
environment that is important for their normal functioning. A failure to maintain this …

Previous studies in native tissues have produced conflicting data on the localization and
metabolic fate of WT and ΔF508 cystic fibrosis transmembrane regulator (CFTR) in the lung …

▪ Abstract The assembly of the cystic fibrosis transmembrane regulator (CFTR) chloride
channel is of interest from the broad perspective of understanding how ion channels and …

The postsynaptic specialisation at glutamatergic synapses is composed of a network of
proteins located within the membrane and the underlying postsynaptic density. The strong …

We investigated the involvement of ClC-3 chloride channels in endosomal acidification by
measurement of endosomal pH and chloride concentration [Cl–] in control versus ClC-3 …

Maintenance of a constant volume is essential for normal cell function. Following cell
swelling, as a consequence of reduction of extracellular osmolarity or increase of …

PDZK1, a multi-PDZ domain containing adaptor protein, interacts with various membrane
proteins, including the high density lipoprotein (HDL) receptor scavenger receptor class B …