Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that
mainly damages the hands and feet, which affects 0.5% to 1.0% of the population …

Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

Chemokines are a family of low molecular weight proteins with an essential role in leukocyte
trafficking during both homeostasis and inflammation. The CC class of chemokines consists …

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases and a
prototypic inflammatory disease, affecting the small joints of the hands and feet. Chemokines …

Rheumatoid arthritis (RA) is an autoimmune disease that commonly causes inflammation
and bone destruction in multiple joints. Inflammatory cytokines, such as IL-6 and TNF-α, play …

Secretion of tumor necrosis factor-α (TNF-α) by macrophages plays a predominant role in
the development and progression of rheumatoid arthritis. We demonstrate that knockdown of …

Chemokines and chemokine receptors are involved in leukocyte recruitment and
angiogenesis underlying the pathogenesis of rheumatoid arthritis (RA) and other …

Angiogenesis is an early and a critical event in the pathogenesis of rheumatoid arthritis
(RA). Neovascularization is dependent on endothelial cell activation, migration and …

Objective CCR2 is a chemokine receptor expressed by monocytes, macrophages, and a
subset of T cells. Its ligand, CCL2 (monocyte chemotactic protein 1), is abundantly present in …

Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the
synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional …