Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

In neurons, the axon and axon initial segment (AIS) are critical structures for action potential
initiation and propagation. Their formation and function rely on tight compartmentalisation, a …

Dynamic protein S-palmitoylation is critical for neuronal function, development, and synaptic
plasticity. Synaptic activity–dependent changes in palmitoylation have been reported for a …

Despite the significant global prevalence of chronic pain, current methods to identify pain
therapeutics often fail translation to the clinic. Phenotypic screening platforms rely on …

Microtubules are polymers composed of αβ-tubulin subunits that provide structure to cells
and play a crucial role in in the development and function of neuronal processes and cilia …

During neural circuit formation, axons navigate several choice points to reach their final
target. At each one of these intermediate targets, growth cones need to switch …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

C-type natriuretic peptide (CNP) is highly expressed in the central nervous system (CNS)
and key to neuronal development; however, a broader role for CNP in the CNS remains …

The primary cilium plays a pivotal role during the embryonic development of vertebrates. It
acts as a somatic signaling hub for specific pathways, such as Sonic Hedgehog signaling. In …

Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and
pathophysiological processes. In recent years, more and more studies have uncovered …