Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …

Abstract BRCA1-associated protein-1 (BAP1) mutations cause a new cancer syndrome, with
a high rate of malignant mesothelioma (MM). Here, we tested the hypothesis that MM …

The BRCA1‐associated protein‐1 (BAP1) tumor predisposition syndrome (BAP1‐TPDS) is a
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …

Twenty years ago, the first familial melanoma susceptibility gene, CDKN 2A, was identified.
Two years later, another high‐penetrance gene, CDK 4, was found to be responsible for …

Importance Patients with germline mutations inBAP1may develop several flesh-colored
melanocyticBAP1–mutated atypical intradermal tumors (MBAITs). These tumors generally …

Summary BRCA-associated protein 1 (BAP1) has emerged as a promising biomarker for
malignant pleural mesothelioma (MPM). Loss of BAP1 expression can occur by a variety of …

Malignant mesothelioma (MM) is uncommon, but very aggressive tumor arising from the
mesothelial cells of pleura, pericardium, peritoneum, and tunica vaginalis. Despite …

The clinical phenotype of BAP1 hereditary cancer predisposition syndrome (MIM 614327)
includes uveal melanoma (UM), cutaneous melanoma (CM), renal cell carcinoma (RCC) …

BAP1 germline mutations predispose to a cancer predisposition syndrome that includes
mesothelioma, cutaneous melanoma, uveal melanoma and other cancers. This co …