Contribution of the TIM-3/Gal-9 immune checkpoint to tropical parasitic diseases
C Bailly - Acta Tropica, 2023 - Elsevier
Neglected tropical parasitic diseases (NTD) are prevalent in many countries and cost-
effective treatments remain urgently needed. Novel approaches have been proposed to …
effective treatments remain urgently needed. Novel approaches have been proposed to …
Filariasis research–from basic research to drug development and novel diagnostics, over a decade of research at the Institute for Medical Microbiology, Immunology …
Filariae are vector borne parasitic nematodes, endemic in tropical and subtropical regions
causing avoidable infections ranging from asymptomatic to stigmatizing and disfiguring …
causing avoidable infections ranging from asymptomatic to stigmatizing and disfiguring …
[HTML][HTML] Filarial lymphedema patients are characterized by exhausted CD4+ T cells
S Horn, M Ritter, K Arndts, D Borrero-Wolff… - Frontiers in Cellular …, 2022 - frontiersin.org
Worldwide, more than 200 million people are infected with filariae which can cause severe
symptoms leading to reduced quality of life and contribute to disability-adjusted life years …
symptoms leading to reduced quality of life and contribute to disability-adjusted life years …
The Role of Inflammation in Lymphedema: A Narrative Review of Pathogenesis and Opportunities for Therapeutic Intervention
C Bowman, SG Rockson - International Journal of Molecular Sciences, 2024 - mdpi.com
Lymphedema is a chronic and progressive disease of the lymphatic system characterized by
inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses …
inflammation, increased adipose deposition, and tissue fibrosis. Despite early hypotheses …
Profound and selective lymphopaenia in primary lymphatic anomaly patients demonstrates the significance of lymphatic-lymphocyte interactions
J Pearce, L Hadcocks, S Mansour… - Frontiers in …, 2023 - frontiersin.org
Introduction The lymphatic system has a pivotal role in immune homeostasis. To better
understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on …
understand this, we investigated the impact of Primary Lymphatic Anomalies (PLA) on …
Similarities and divergences in the metabolism of immune cells in cancer and helminthic infections
D Esperante, MIM Gutiérrez, ME Issa… - Frontiers in …, 2023 - frontiersin.org
Energetic and nutritional requirements play a crucial role in shaping the immune cells that
infiltrate tumor and parasite infection sites. The dynamic interaction between immune cells …
infiltrate tumor and parasite infection sites. The dynamic interaction between immune cells …
Immune checkpoint status and exhaustion‐related phenotypes of CD8+ T cells from the tumor‐draining regional lymph nodes in breast cancer
Background Functional status of T cells determines the responsiveness of cancer patients to
immunotherapeutic interventions. Even though T cell‐mediated immunity is inaugurated in …
immunotherapeutic interventions. Even though T cell‐mediated immunity is inaugurated in …
[HTML][HTML] Differences in Cytokine Expression at Baseline and in Response to Mineral Stimulation by Peripheral Blood Mononuclear Cells from Podoconiosis Cases and …
M Negash, T Girma, M Chanyalew… - Tropical Medicine and …, 2024 - mdpi.com
Epidemiological, histological, and immunogenetic studies suggest that podoconiosis (a non-
infectious tropical lymphoedema affecting approximately 4 million people globally) is an …
infectious tropical lymphoedema affecting approximately 4 million people globally) is an …
Reduced Type 2 Innate Lymphocyte Cell Frequencies in Patent Wuchereria bancrofti-Infected Individuals
RSE Tamadaho, J Osei-Mensah, K Arndts, LB Debrah… - Pathogens, 2023 - mdpi.com
Approximately 51 million individuals suffer from lymphatic filariasis (LF) caused mainly by
the filarial worm Wuchereria bancrofti. Mass drug administration (MDA) programs led to a …
the filarial worm Wuchereria bancrofti. Mass drug administration (MDA) programs led to a …
Stage-Dependent Increase of Systemic Immune Activation and CCR5+CD4+ T Cells in Filarial Driven Lymphedema in Ghana and Tanzania
AA Rahamani, S Horn, M Ritter, A Feichtner… - Pathogens, 2023 - mdpi.com
Chronic lymphedema caused by infection of Wuchereria bancrofti is a disfiguring disease
that leads to physical disability, stigmatization, and reduced quality of life. The edematous …
that leads to physical disability, stigmatization, and reduced quality of life. The edematous …