A subject of extensive study in evolutionary theory has been the issue of how neutral,
redundant copies can be maintained in the genome for long periods of time. Concurrently …

In this essay, we revisit the status of yeast as a model system for biology. We first summarize
important contributions of yeast to eukaryotic biology that we anticipated in 1988 in our first …

Large structural variations (SVs) within genomes are more challenging to identify than
smaller genetic variants but may substantially contribute to phenotypic diversity and …

Polyploidy is observed across the tree of life, yet its influence on evolution remains
incompletely understood,,,. Polyploidy, usually whole-genome duplication, is proposed to …

Evolution of large asexual cell populations underlies∼ 30% of deaths worldwide, including
those caused by bacteria, fungi, parasites, and cancer. However, the dynamics underlying …

The dynamics of adaptation determine which mutations fix in a population, and hence how
reproducible evolution will be. This is central to understanding the spectra of mutations …

Intracellular processes rarely work in isolation but continually interact with the rest of the cell.
In microbes, for example, we now know that gene expression across the whole genome …

The yeast Saccharomyces cerevisiae has been instrumental in the fermentation of foods and
beverages for millennia. In addition to fermentations like wine, beer, cider, sake, and bread …

What is the nature of the genetic changes underlying phenotypic evolution? We have
catalogued 1008 alleles described in the literature that cause phenotypic differences among …

Association studies provide genome-wide information about the genetic basis of complex
disease, but medical research has focused primarily on protein-coding variants, owing to the …