Osteonecrosis, which is typically induced by trauma, glucocorticoid abuse, or alcoholism, is
one of the most severe diseases in clinical orthopedics. Osteonecrosis often leads to joint …

Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Repair of large bone defects represents a major challenge for orthopedic surgeons. The
newly formed microvessels inside grafts play a crucial role in successful bone tissue …

Clinical translation of cell‐based products is hampered by their limited predictive in vivo
performance. To overcome this hurdle, engineering strategies advocate to fabricate tissue …

Craniofacial deformities (CFDs) develop following oncological resection, trauma, or
congenital disorders. Trauma is one of the top five causes of death globally, with rates …

The management and definitive treatment of segmental bone defects in the setting of acute
trauma, fracture non-union, revision joint arthroplasty, and tumor surgery are challenging …

Traditional bone tissue engineering (BTE) strategies induce direct bone-like matrix formation
by mimicking the embryological process of intramembranous ossification. However, the …

The craniofacial region is anatomically complex and is of critical functional and cosmetic
importance, making reconstruction challenging. The limitations of current surgical options …

In order to solve the clinical challenges related to bone grafting, several tissue engineering
(TE) strategies have been proposed to repair critical-sized defects. Generally, the classical …

Background Acute bone loss after fracture is associated with various effects on the complete
recovery process and a risk of secondary fractures among patients. Studies have reported …