The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …

Altered metabolism and deregulated cellular energetics are now considered a hallmark of
all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor …

Aging happens to all of us as we live. Thanks to the improved living standard and discovery
of life-saving medicines, our life expectancy has increased substantially across the world in …

Background Colorectal cancer (CRC) is one of the most common forms of cancer worldwide.
The tumor microenvironment plays a key role in promoting the occurrence of …

Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Forkhead box O (FOXO) proteins are a family of transcription factors with four members in
mammals, namely FOXO1, FOXO3a, FOXO4, and FOXO6. FOXO factors, originally identified …

Breast cancer (BC) is the most common malignancy among women worldwide. Like many
other cancers, BC therapy is challenging and sometimes frustrating. In spite of the various …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

FOXO transcription factors are negatively regulated by the PI3K-PKB/AKT signaling pathway
and have been mainly considered to be tumor suppressors due to their inhibitory effect on …

FOXO1 transcription factors affect a number of cell types that are important in the host
response. Cell types whose functions are modulated by FOXO1 include keratinocytes in the …