How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond

J Rimando, SR McCurdy, L Luznik - Blood, 2023 - ashpublications.org
Advances in conditioning, graft-versus-host disease (GVHD) prophylaxis and antimicrobial
prophylaxis have improved the safety of allogeneic hematopoietic cell transplantation (HCT) …

Steroid-refractory chronic graft-versus-host disease: treatment options and patient management

D Wolff, G Fatobene, V Rocha, N Kröger… - Bone marrow …, 2021 - nature.com
Chronic graft-versus-host disease (cGVHD) is one of the major causes of late mortality after
allogenic hematopoietic stem cell transplantation. Moderate-to-severe cGVHD is associated …

National Marrow Donor Program–sponsored multicenter, phase II trial of HLA-mismatched unrelated donor bone marrow transplantation using post-transplant …

BE Shaw, AM Jimenez-Jimenez, LJ Burns… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Hematopoietic cell transplantation (HCT) is curative for hematologic disorders,
but outcomes are historically inferior when using HLA-mismatched donors. Despite …

HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis

M Gooptu, R Romee, A St. Martin… - Blood, The Journal …, 2021 - ashpublications.org
Posttransplant cyclophosphamide (PTCy) graft-versus-host disease (GVHD) prophylaxis has
enabled haploidentical (Haplo) transplantation to be performed with results similar to those …

Post-transplant cyclophosphamide for graft-versus-host disease prophylaxis in HLA matched sibling or matched unrelated donor transplant for patients with acute …

A Ruggeri, M Labopin, A Bacigalupo… - Journal of hematology & …, 2018 - Springer
Background Experience using post-transplant cyclophosphamide (PT-Cy) as graft-versus-
host disease (GVHD) prophylaxis in allogeneic stem cell transplantation (HSCT) from …

Bone marrow versus mobilized peripheral blood stem cells in haploidentical transplants using posttransplantation cyclophosphamide

A Ruggeri, M Labopin, A Bacigalupo, Z Gülbas, Y Koc… - Cancer, 2018 - Wiley Online Library
BACKGROUND Incidence of graft‐versus‐host disease (GVHD) in haploidentical bone
marrow (BM) transplants using posttransplantion cyclophosphamide (PT‐Cy) is low …

Reduced post-transplant cyclophosphamide dose with antithymocyte globulin in peripheral blood stem cell haploidentical transplantation

R Duléry, F Malard, E Brissot, A Banet… - Bone Marrow …, 2023 - nature.com
Post-transplant cyclophosphamide (PT-Cy) is effective for graft-versus-host disease (GVHD)
prophylaxis, but it may cause dose-dependent toxicities, particularly in frail patients …

Outcomes of haploidentical vs matched sibling transplantation for acute myeloid leukemia in first complete remission

A Rashidi, M Hamadani, MJ Zhang, HL Wang… - Blood …, 2019 - ashpublications.org
HLA-haploidentical hematopoietic cell transplantation (Haplo-HCT) using
posttransplantation cyclophosphamide (PT-Cy) has improved donor availability. However, a …

Post-transplant cyclophosphamide after matched sibling, unrelated and haploidentical donor transplants in patients with acute myeloid leukemia: a comparative study …

J Sanz, JE Galimard, M Labopin, B Afanasyev… - Journal of hematology & …, 2020 - Springer
Background The use of post-transplant cyclophosphamide (PTCy) is highly effective in
preventing graft-versus-host disease (GVHD) in the haploidentical (Haplo) transplant setting …

Combining post-transplant cyclophosphamide with antithymocyte globulin for graft-versus-host disease prophylaxis in hematological malignancies

R Duléry, E Brissot, M Mohty - Blood Reviews, 2023 - Elsevier
In search of an ideal partner or alternative to conventional immunosuppressive agents,
rabbit anti-thymocyte globulin (ATG) and, more recently, post-transplant cyclophosphamide …