Recent advances in single-cell technologies have enabled high-throughput molecular
profiling of cells across modalities and locations. Single-cell transcriptomics data can now …

T cells express T cell receptors (TCRs) composed of somatically recombined TCRα and
TCRβ chains, which mediate recognition of major histocompatibility complex (MHC)–antigen …

Antiretroviral therapy is highly effective in suppressing human immunodeficiency virus (HIV).
However, eradication of the virus in individuals with HIV has not been possible to date …

Despite the resounding clinical success in cancer treatment of antibodies that block the
interaction of PD1 with its ligand PDL1, the mechanisms involved remain unknown. A major …

Here, we report an update of the VDJdb database with a substantial increase in the number
of T-cell receptor (TCR) sequences and their cognate antigens. The update further provides …

The T cells of the immune system can target tumors and clear solid cancers following tumor-
infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a …

Colonic antigen-experienced lymphocytes such as tissue-resident memory CD8+ T cells can
respond rapidly to repeated antigen exposure. However, their cellular phenotypes and the …

We performed a phase 1 clinical trial to evaluate outcomes in patients receiving donor-
derived CD19-specific chimeric antigen receptor (CAR) T cells for B-cell malignancy that …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

The regulatory and effector functions of T cells are initiated by the binding of their cell-
surface T cell receptor (TCR) to peptides presented by major histocompatibility complex …