Protein–ligand interactions are of fundamental importance in almost all processes in living
organisms. The ligands comprise small molecules, drugs or biological macromolecules and …

Paramagnetic metal ions offer outstanding opportunities for protein studies by nuclear
magnetic resonance (NMR) spectroscopy. The paramagnetic effects manifested in the NMR …

Recent advances in NMR methodology and techniques allow the structural investigation of
biomolecules of increasing size with atomic resolution. NMR spectroscopy is especially well …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

The broad-spectrum antiviral arbidol (Arb) inhibits cell entry of enveloped viruses by
blocking viral fusion with host cell membrane. To better understand Arb mechanism of …

Solvent paramagnetic relaxation enhancement (sPRE) is a versatile nuclear magnetic
resonance (NMR)-based method that allows characterization of the structure and dynamics …

Signals between a cell and its environment are often transmitted through membrane
proteins; therefore, many membrane proteins, including G protein-coupled receptors …

In order to understand the conformational behavior of intrinsically disordered proteins (IDPs)
and their biological interaction networks, the detection of residual structure and long-range …

Characterisation of the structure and dynamics of large biomolecules and biomolecular
complexes by NMR spectroscopy is hampered by increasing overlap and severe …

TX100 (Triton X-100) is a typical nonionic surfactant that is widely used in biology. However,
the detailed aggregated conformation of TX100, such as the boundary between the polar …