Histone posttranslational modifications are key components of diverse processes that
modulate chromatin structure. These marks function as signals during various chromatin …

Polyamines are aliphatic cations with multiple functions and are essential for life. Cellular
polyamine levels are regulated by multiple pathways such as synthesis from amino acid …

Histone H3 is specifically phosphorylated during both mitosis and meiosis in patterns that
are specifically coordinated in both space and time. Histone H3 phosphorylation may initiate …

Eukaryotic cells must possess mechanisms for condensing and decondensing chromatin.
Chromatin condensation is particularly evident during mitosis and cell death induced by …

Histone acetylation and phosphorylation have separately been suggested to affect
chromatin structure and gene expression. Here we report that these two modifications are …

Biogenic polyamines, such as putrescine, spermidine, and spermine are small organic
polycations involved in numerous diverse biological processes. These compounds play an …

Multiple covalent modifications exist in the amino-terminal tails of core histones, but whether
a relationship exists between them is unknown. We examined the relationship between …

Histone H3 (H3) phosphorylation at Ser 10 occurs during mitosis in eukaryotes and was
recently shown to play an important role in chromosome condensation in Tetrahymena …

The nucleosome and chromatin fiber provide the common structural framework for
transcriptional control in eukaryotes. The folding of DNA within these structures can both …

Experimental evidence supported by epidemiological findings suggests that solar ultraviolet
(UV) irradiation is the most important environmental carcinogen leading to the development …