Several systems, including contractile tail bacteriophages, the type VI secretion system and
R-type pyocins, use a multiprotein tubular apparatus to attach to and penetrate host cell …

The second decade of the twenty-first century witnessed a new challenge in the handling of
microscopy data. Big data, data deluge, large data, data compliance, data analytics, data …

We present a new software package called Focus that interfaces cryo-transmission electron
microscopy (cryo-EM) data collection with computer image processing. Focus creates a user …

Bacteria use rapid contraction of a long sheath of the type VI secretion system (T6SS) to
deliver effectors into a target cell. Here, we present an atomic-resolution structure of a native …

Cryo-electron microscopy (cryo-EM), the structural analysis of samples embedded in
vitreous ice, is a powerful approach for determining three-dimensional (3D) structures of …

Inflammasomes are multiprotein complexes that control the innate immune response by
activating caspase-1, thus promoting the secretion of cytokines in response to invading …

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens
of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system …

Here, we demonstrate atomic-resolution scanning transmission electron microscopy (STEM)
imaging of light elements in small organic molecules on graphene. We use low-dose, room …

ABC toxins are pore-forming virulence factors produced by pathogenic bacteria. YenTcA is
the pore-forming and membrane binding A subunit of the ABC toxin YenTc, produced by the …