Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

Introduction Advances in our understanding of the molecular genetics and epigenetics of
colorectal cancer have led to novel insights into the pathogenesis of this common cancer …

Simple Summary Colorectal cancer is the second leading cause of cancer-related deaths in
the United States with an overall 5-year survival of 65%. While there have been many …

Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer, the third leading
cause of cancer-related deaths, and has been on the rise among young adults in the United …

The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of
colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from …

Context.—Colorectal cancer is a heterogeneous disease entity with 3 molecular
carcinogenesis pathways and 2 morphologic multistep pathways. Right-sided colon cancers …

Mucus serves as the chief protective barrier against pathogenic and mechanical insults in
respiratory, gastrointestinal, and urogenital tracts. Altered mucin expression, the major …

The development of immune checkpoint inhibitors is becoming a promising approach to fight
cancers. Antibodies targeting immune checkpoint proteins such as CTLA-4 and PD-1 can …