Diabetes mellitus (DM), one of the most common life-threatening illnesses worldwide, is a
group of metabolic diseases, characterized by sustained hyperglycemia. The global …

Ovarian cancer is the leading cause of death from gynecologic malignancy in the Western
world. This is due, in part, to the fact that despite standard treatment of surgery and …

Chemotherapy-induced peripheral neuropathy (CIPN) characterized by loss of sensory
sensitivity and pain in hands and feet is the major dose-limiting toxicity of many …

Biguanides are compounds in which two guanidine moieties are fused to form a highly
conjugated system. Biguanides are highly basic and hence they are available as salts …

Hematologic malignancies (HMs) mainly include acute and chronic leukemia, lymphoma,
myeloma and other heterogeneous tumors that seriously threaten human life and health …

Metformin exerts antitumor effects mainly through AMP-activated protein kinase [AMPK]
activation and phosphatidylinositol 3-kinase [PI3K]-Akt-mammalian target of rapamycin …

Cancer stem cells (CSCs) refer to a subpopulation of cancer cells responsible for
tumorigenesis, metastasis, and drug resistance. Increasing evidence suggests that CSC …

Epithelial ovarian cancer (EOC) is the most lethal of all gynecological cancers, and
encompasses distinct histological subtypes that have specific genetic and tissues-of-origin …

Failure in ovarian cancer therapy, following cytoreduction and chemotherapy, is related to
the presence of cancer stem cells-a small subpopulation of cells resistant to chemotherapy …

Ovarian cancer continues to be the leading cause of death from gynecological cancers.
Despite inconsistent results, patients with metabolic abnormalities, including obesity and …