Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …

The WT1 (Wilms' tumour 1) gene encodes a zinc finger transcription factor and RNA-binding
protein that direct the development of several organs and tissues. WT1 manifests both …

The epithelial-to-mesenchymal transition (EMT) is an essential biological process during
embryonic development that is also implicated in cancer metastasis. While the …

Most human genes produce multiple splicing isoforms with distinct functions. To
systematically understand splicing regulation, we conducted an unbiased screen and …

Ataxia oculomotor apraxia type 2 (AOA2) is an autosomal recessive neurodegenerative
disorder characterized by cerebellar ataxia and oculomotor apraxia. The gene mutated in …

Herculean efforts by the Wellcome Sanger Institute, the National Cancer Institute, and the
National Human Genome Research Institute to sequence thousands of tumors representing …

Regulation of tau exon 10 splicing plays an important role in tauopathy. One of the cis
elements regulating tau alternative splicing is a stem-loop structure at the 5′ splice site of …

In 1990, mutations of the Wilms' tumor-1 gene (WT1), encoding a transcription factor in the
embryonic kidney, were found in 10–15% of Wilms' tumors; germline WT1 mutations were …

MicroRNAs (miRNAs) are central regulators of gene expression, and a large fraction of them
are encoded in introns of RNA polymerase II transcripts. Thus, the biogenesis of intronic …

Adenoviruses replicate primarily in the host cell nucleus, and it is well established that
adenovirus infection affects the structure and function of host cell nucleoli in addition to …