The action of phytohormones in plants requires the spatiotemporal regulation of their
accumulation and responses at various levels. Recent studies reveal an emerging …

Lissencephaly ('smooth brain') is a severe brain disease associated with numerous
symptoms, including cognitive impairment, and shortened lifespan. The main causative …

The transcriptional response to auxin is critical for root and vascular development during
Arabidopsis embryogenesis. Auxin induces the degradation of AUXIN/INDOLE-3-ACETIC …

The embryos of seed plants develop with an apical shoot pole and a basal root pole. In
Arabidopsis, the topless-1 (tpl-1) mutation transforms the shoot pole into a second root pole …

Treacher Collins syndrome (TCS) is a rare congenital disorder of craniofacial development
that arises as the result of mutations in the TCOF1 gene, which encodes a nucleolar …

Centrosomes and their component centrioles represent the principal microtubule organizing
centers of animal cells. Here, we show that the gene underlying orofaciodigital syndrome 1 …

TOPLESS (TPL) and TOPLESS-related (TPR) proteins comprise a conserved family of plant
transcriptional corepressors that are related to Tup1, Groucho, and TLE (transducin-like …

A subset of WD40 proteins that contain a DWD motif (for DDB1 binding WD40) is reported to
act as substrate receptors for DDB1-CUL4-ROC1 (for Damaged DNA Binding 1–Cullin 4 …

One of the most significant features of plant development is the way in which it can be
elaborated and modulated throughout the life of the plant, an ability that is conferred by …

The transcription factor Flo8 is essential for filamentous growth in Saccharomyces cerevisiae
and is regulated under the cAMP/protein kinase A (PKA) pathway. To determine whether a …