Adaptation to any undesirable change in the environment dictates the survivability of many
microorganisms, with such changes generating a quick and suitable response, which guides …

M. tuberculosis, an etiological agent of tuberculosis, requires a long treatment regimen due
to its ability to respond to stress and persist inside the host. The second messenger (p) …

The genus Mycobacterium includes a variety of species with differing phenotypic properties,
including growth rate, pathogenicity and environment-and host-specificity. Although many …

During infection, the host restrains Mycobacterium tuberculosis (Mtb) from proliferating by
imposing an arsenal of stresses. Despite this onslaught of attacks, Mtb is able to persist for …

Stringent response is a conserved stress response mechanism in which bacteria employ the
second messengers guanosine tetraphosphate and guanosine pentaphosphate [collectively …

Latency in Mycobacterium tuberculosis poses a barrier in its complete eradication.
Overexpression of certain genes is one of the factors that help these bacilli survive inside the …

The build-up of formaldehyde, a highly reactive molecule is cytotoxic and must be eliminated
for the organism's survival. Formaldehyde detoxification system is found in nearly all …

Rifampicin and its derivatives are at the forefront of the current standard chemotherapeutic
regimen for active tuberculosis; they act by inhibiting the transcription activity of prokaryotic …

Transcriptional factors such as the TetR family of transcriptional regulators (TFTRs) are
widely found amongst bacteria, including mycobacteria, and are accountable for their …

The success of Mycobacterium tuberculosis as one of the dreaded human pathogens lies in
its ability to utilize different defense mechanisms in response to the varied environmental …