SP-A and SP-D: dual functioning immune molecules with antiviral and immunomodulatory properties

A Watson, J Madsen, HW Clark - Frontiers in Immunology, 2021 - frontiersin.org
Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

Respiratory syncytial virus—a comprehensive review

AT Borchers, C Chang, ME Gershwin… - Clinical reviews in allergy …, 2013 - Springer
Respiratory syncytial virus (RSV) is amongst the most important pathogenic infections of
childhood and is associated with significant morbidity and mortality. Although there have …

Respiratory syncytial virus uses CX3CR1 as a receptor on primary human airway epithelial cultures

SM Johnson, BA McNally, I Ioannidis, E Flano… - PLoS …, 2015 - journals.plos.org
Respiratory syncytial virus (RSV) is the most frequent cause of lower respiratory disease in
infants, but no vaccine or effective therapy is available. The initiation of RSV infection of …

Structure and function of respiratory syncytial virus surface glycoproteins

JS McLellan, WC Ray, ME Peeples - Challenges and opportunities for …, 2013 - Springer
The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the
attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of …

The viral protein corona directs viral pathogenesis and amyloid aggregation

K Ezzat, M Pernemalm, S Pålsson, TC Roberts… - Nature …, 2019 - nature.com
Artificial nanoparticles accumulate a protein corona layer in biological fluids, which
significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses …

The journey to a respiratory syncytial virus vaccine

A Mejias, R Rodríguez-Fernández, S Oliva… - Annals of Allergy …, 2020 - Elsevier
Objective The high burden associated with respiratory syncytial virus (RSV) has made the
development of RSV vaccine (s) a global health high priority. This review summarizes the …

Lipid–protein and protein–protein interactions in the pulmonary surfactant system and their role in lung homeostasis

O Cañadas, B Olmeda, A Alonso… - International journal of …, 2020 - mdpi.com
Pulmonary surfactant is a lipid/protein complex synthesized by the alveolar epithelium and
secreted into the airspaces, where it coats and protects the large respiratory air–liquid …

Collectins: players of the innate immune system

JK van de Wetering, LMG van Golde… - European Journal of …, 2004 - Wiley Online Library
Collectins are a family of collagenous calcium‐dependent defense lectins in animals. Their
polypeptide chains consist of four regions: a cysteine‐rich N‐terminal domain, a collagen …

Macrophage immunoregulatory pathways in tuberculosis

MVS Rajaram, B Ni, CE Dodd, LS Schlesinger - Seminars in immunology, 2014 - Elsevier
Macrophages, the major host cells harboring Mycobacterium tuberculosis (M. tb), are a
heterogeneous cell type depending on their tissue of origin and host they are derived from …

Bitter-sweet symphony: glycan–lectin interactions in virus biology

W Van Breedam, S Pöhlmann… - FEMS microbiology …, 2014 - academic.oup.com
Glycans are carbohydrate modifications typically found on proteins or lipids, and can act as
ligands for glycan-binding proteins called lectins. Glycans and lectins play crucial roles in …