Many viruses induce shutoff of host gene expression (host shutoff) as a strategy to take over
cellular machinery and evade host immunity. Without host shutoff activity, these viruses …

The ability to shut off host gene expression is a shared feature of many viral infections, and it
is thought to promote viral replication by freeing host cell machinery and blocking immune …

Viral replication significantly alters the gene expression landscape of infected cells. Many of
these changes are driven by viral manipulation of host transcription or translation machinery …

On entry into the body herpes simplex viruses (HSV) replicate in a series of steps that
involves derepression of viral DNA activated by VP16, a virion protein, and sequential …

Background Host shutoff refers to the widespread downregulation of host gene expression
and has emerged as a key process that facilitates the reallocation of cellular resources for …

Bovine herpesvirus type 1 (BHV-1) is a neurotropic herpesvirus that causes infectious
rhinotracheitis and vulvovaginitis in cattle. The virion host shutoff protein encoded by the …

Duck plague virus (DPV) belongs to the alphaherpesvirinae and causes high morbidity and
mortality in waterfowl. UL47 is a large abundant structural protein in DPV, which means that …

Duck enteritis virus (DEV) is a member of the Alphaherpesvirinae subfamily. The
characteristics of some DEV genes have been reported. However, information regarding the …

A key property of herpes simplex viruses (HSVs) is their ability to establish latent infection in
sensory or autonomic ganglia and to reactivate on physical, hormonal, or emotional stress …

An alphaherpesvirus carries dozens of viral proteins in the envelope, tegument and capsid
structure, and each protein plays an indispensable role in virus adsorption, invasion …