Hyaline cartilage plays a critical role in maintaining joint function and pain. However, the
lack of blood supply, nerves, and lymphatic vessels greatly limited the self-repair and …

Articular cartilage defects represent an inciting factor for future osteoarthritis (OA) and
degenerative joint disease progression. Despite multiple clinically available therapies that …

The rapid development of tissue engineering makes it an effective strategy for repairing
cartilage defects. The significant advantages of injectable hydrogels for cartilage injury …

Clinically, microfracture is the most commonly applied surgical technique for cartilage
defects. However, an increasing number of studies have shown that the clinical …

Cell and tissue engineering approaches for articular cartilage regeneration increasingly
focus on mesenchymal stem cells (MSCs) as allogeneic cell sources, based on availability …

The repair of articular cartilage defects is still challenging in the fields of orthopedics and
maxillofacial surgery due to the avascular structure of articular cartilage and the limited …

Biomaterials play a core role in cartilage repair and regeneration. The success or failure of
an implanted biomaterial is largely dependent on host response following implantation. Host …

Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering
approaches are primarily based on collagen type I devices that are associated with …

In regenerative medicine and tissue engineering, the possibility to:(I) customize the shape
and size of scaffolds,(II) develop highly mimicked tissues with a precise digital control,(III) …

Because of its ideal degradation rate and features, oxidized alginate (OA) is selected as an
appropriate substitute and has been introduced into hydrogels, microspheres, 3D …