Data that have a multilevel structure occur frequently across a range of disciplines, including
epidemiology, health services research, public health, education and sociology. We …

The hazard function plays a central role in survival analysis. In a homogeneous population,
the distribution of the time to event, described by the hazard, is the same for each individual …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of
hospitalization for heart failure or death from cardiovascular causes among patients with …

Importance Hydroxychloroquine, with or without azithromycin, has been considered as a
possible therapeutic agent for patients with coronavirus disease 2019 (COVID-19) …

Background Experimental and clinical evidence supports the role of inflammation in
atherosclerosis and its complications. Colchicine is an orally administered, potent …

Objective To determine changes in the incidence of dementia between 1988 and 2015.
Methods This analysis was performed in aggregated data from individuals> 65 years of age …

Background The cardiovascular effects of adding once-weekly treatment with exenatide to
usual care in patients with type 2 diabetes are unknown. Methods We randomly assigned …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

Importance Although colonoscopy is frequently performed in the United States, there is
limited evidence to support threshold values for physician adenoma detection rate as a …

Since a detailed inventory of endothelial cell (EC) heterogeneity in breast cancer (BC) is
lacking, here we perform single cell RNA-sequencing of 26,515 cells (including 8433 ECs) …