Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan

Z Papp, I Édes, S Fruhwald, SG De Hert… - International journal of …, 2012 - Elsevier
The molecular background of the Ca2+-sensitizing effect of levosimendan relates to its
specific interaction with the Ca2+-sensor troponin C molecule in the cardiac myofilaments …

Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome

J Schumann, EC Henrich, H Strobl… - Cochrane Database …, 2018 - cochranelibrary.com
Background Cardiogenic shock (CS) and low cardiac output syndrome (LCOS) as
complications of acute myocardial infarction (AMI), heart failure (HF) or cardiac surgery are …

[PDF][PDF] 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

P Ponikowski, AA Voors, SD Anker… - Kardiologia Polska …, 2016 - journals.viamedica.pl
5.2. 1. Ocena funkcji skurczowej lewej komory...................................... 1052 5.2. 2. Ocena
funkcji rozkurczowej lewej komory...................................... 1052 5.2. 3. Ocena funkcji prawej …

[PDF][PDF] Guía ESC 2016 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica

A Ponikowski, AA Voors, SD Anker, H Bueno… - Revista espanola de …, 2016 - orbi.uliege.be
Se recomienda a los profesionales de la salud que tengan en consideración la presente
guía de la ESC en la toma de decisiones clínicas en su ejercicio diario, así como en la …

Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies

G Landoni, G Biondi-Zoccai, M Greco… - Critical care …, 2012 - journals.lww.com
Objective: Catecholaminergic inotropes have a place in the management of low output
syndrome and decompensated heart failure but their effect on mortality is debated …

[HTML][HTML] Levosimendan: current data, clinical use and future development

MS Nieminen, S Fruhwald, LMA Heunks… - Heart, lung and …, 2013 - ncbi.nlm.nih.gov
Levosimendan is an inodilator indicated for the short-term treatment of acutely
decompensated severe chronic heart failure, and in situations where conventional therapy is …

Wytyczne ESC dotyczace diagnostyki i leczenia ostrej i przewlekłej niewydolności serca w 2016 roku

P Ponikowski, AA Voors, SD Anker… - Kardiologia …, 2016 - research.monash.edu
Abstract Stowarzyszenia ESC: Acute Cardiovascular Care Association (ACCA), European
Association for Cardiovascular Prevention and Rehabilitation (EACPR), European …

Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials

CL Tacon, J McCaffrey, A Delaney - Intensive care medicine, 2012 - Springer
Purpose Dobutamine is recommended for patients with severe heart failure; however
uncertainty exists as to its effect on mortality. This study aims to critically review the literature …

Cardiac inotropes: current agents and future directions

G Hasenfuss, JR Teerlink - European heart journal, 2011 - academic.oup.com
Intrinsic inotropic stimulation of the heart is central to the regulation of cardiovascular
function, and exogenous inotropic therapies have been used clinically for decades …

[HTML][HTML] Levosimendan meta-analyses: Is there a pattern in the effect on mortality?

P Pollesello, J Parissis, M Kivikko, VP Harjola - International journal of …, 2016 - Elsevier
Background Levosimendan is an inodilator developed for treatment of acute heart failure
and other cardiac conditions where the use of an inodilator is considered appropriate …