Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Cancer is one of the leading causes of death in the United States, and more than 1.5 million
new cases and more than 0.5 million deaths were reported during 2010 in the United States …

Although prostate cancer is the most common malignancy to affect men in the Western
world, the molecular mechanisms underlying its development and progression remain …

Sex-steroid hormones have been investigated for decades for their oncogenic properties in
hormone-dependent cancers. The increasing body of knowledge on the biological actions of …

Prostate cancer (PCa) is a major health care problem because of its high prevalence, health‐
related costs, and mortality. Epidemiological studies have suggested an important role of …

Abstract 5 α-Reductase types 1 and 2, encoded by SRD5A1 and SRD5A2, are the two
enzymes that can catalyze the conversion of testosterone to dihydrotestosterone, the most …

Purpose: Prostate cancer is a heterogeneous genetic disease, and molecular methods for
predicting prognosis in patients with aggressive form of the disease are urgently needed to …

Prostate cancer is uniquely dependent on androgens. Despite years of research on the
relationship between androgens and prostate cancer, many questions remain as to the …

Abstract In the United States, cancer is one of the major causes of death. In 2010 alone, over
1.5 million fresh instances were recorded and over 0.5 billion died. After the completion of …

Recent evidence indicates that microRNAs might participate in prostate cancer initiation,
progression and treatment response. Germline variations in microRNAs might alter target …