At the colonization site of a foreign entity, plant cells alter their trajectory of growth and
development. The resulting structure–a plant gall–accommodates various needs of the …

Bacteria have acquired multiple systems to expose proteins on their surface, release them in
the extracellular environment or even inject them into a neighboring cell. Protein secretion …

Bacterial cell growth and division require the coordinated action of enzymes that synthesize
and degrade cell wall polymers. Here, we identify enzymes that cleave the d-arabinan core …

Mycobacteria possess Mce transporters that import lipids and are thought to function
analogously to ATP-binding cassette (ABC) transporters. However, whereas ABC …

Tuberculosis (TB) is a major public health concern for all ages. However, the disease
presents a larger challenge in pediatric populations, partially owing to the lack of reliable …

Tuberculosis is the deadliest infectious disease worldwide. Although the BCG vaccine is
widely used, it does not efficiently protect against pulmonary tuberculosis and an improved …

Pathogenic mycobacteria encounter multiple environments during macrophage infection.
Temporally, the bacteria are engulfed into the phagosome, lyse the phagosomal membrane …

Functional genomics analysis of Mycobacterium abscessus clinical isolates from chronically
infected patients to identify genes under strong evolutionary pressure during lung adaptation …

Mycobacteria, including the infamous pathogen Mycobacterium tuberculosis, are high-GC
Gram-positive bacteria with a distinctive cell envelope. Although there is a typical inner …

Host metabolism reprogramming is a key feature of Mycobacterium tuberculosis (Mtb)
infection that enables the survival of this pathogen within phagocytic cells and modulates the …