SGK1 in human cancer: emerging roles and mechanisms

Y Sang, P Kong, S Zhang, L Zhang, Y Cao… - Frontiers in …, 2021 - frontiersin.org
Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …

Colon cancer transcriptome

K Mokhtari, M Peymani, M Rashidi… - Progress in biophysics …, 2023 - Elsevier
Over the last four decades, methodological innovations have continuously changed
transcriptome profiling. It is now feasible to sequence and quantify the transcriptional outputs …

[HTML][HTML] Jiawei Shoutai Pill promotes decidualization by regulating the SGK1/ENaC pathway in recurrent spontaneous abortion

X Di, Z Duan, Y Ma, X Song, Y Hao, G Li, Z Tan… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Jiawei Shoutai Pill (JWSTW) is a traditional
herbal formula for recurrent spontaneous abortion (RSA). Although JWSTW significantly …

Discovery of herbacetin as a novel SGK1 inhibitor to alleviate myocardial hypertrophy

S Zhang, Y Wang, M Yu, Y Shang, Y Chang… - Advanced …, 2022 - Wiley Online Library
Cardiac hypertrophy is a pivotal pathophysiological step of various cardiovascular diseases,
which eventually leads to heart failure and death. Extracts of Rhodiola species (Ext. R), a …

E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1

P Li, H Xu, L Yang, M Zhan, Y Shi, C Zhang… - Cell death & …, 2022 - nature.com
Long noncoding RNAs (lncRNAs) participate in biological processes in multiple types of
tumors. However, the regulatory patterns of lncRNAs in prostate cancer remain largely …

The prospect of serum and glucocorticoid-inducible kinase 1 (SGK1) in cancer therapy: a rising star

R Zhu, G Yang, Z Cao, K Shen… - … in medical oncology, 2020 - journals.sagepub.com
Serum and glucocorticoid-inducible kinase 1 (SGK1) is an AGC kinase that has been
reported to be involved in a variety of physiological and pathological processes. Recent …

Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors

H Jang, Y Park, J Jang - Frontiers in Pharmacology, 2022 - frontiersin.org
Serum and glucocorticoid-regulated kinase 1 (SGK1) is a serine/threonine kinase belonging
to the protein kinase A, G, and C (AGC) family. Upon initiation of the phosphoinositide 3 …

Induction of SGK1 via glucocorticoid-influenced clinical outcome of triple-negative breast cancer patients

J Zhang, Y Miki, E Iwabuchi, J Xu, A Kanai… - Breast Cancer Research …, 2023 - Springer
Purpose Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive
breast malignancy. Glucocorticoid (GC)–glucocorticoid receptor (GR) pathway plays a …

Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis

K Arimoto, S Miyauchi, TD Troutman, Y Zhang… - Nature …, 2023 - nature.com
While immunotherapy has emerged as a breakthrough cancer therapy, it is only effective in
some patients, indicating the need of alternative therapeutic strategies. Induction of cancer …

[HTML][HTML] Inhibition of SGK1 confers vulnerability to redox dysregulation in cervical cancer

M Wang, Y Xue, L Shen, P Qin, X Sang, Z Tao, J Yi… - Redox biology, 2019 - Elsevier
Cervical cancer has poor prognosis and patients are often diagnosed at advanced stages of
the disease with limited treatment options. There is thus an urgent need for the discovery of …