Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success

G Copp, KP Robb, S Viswanathan - Cellular & Molecular Immunology, 2023 - nature.com
Osteoarthritis (OA) is a degenerative multifactorial disease with concomitant structural,
inflammatory, and metabolic changes that fluctuate in a temporal and patient-specific …

Does the source of mesenchymal stem cell have an effect in the management of osteoarthritis of the knee? Meta-analysis of randomized controlled trials

M Jeyaraman, S Muthu, PA Ganie - Cartilage, 2021 - journals.sagepub.com
Study Design Meta-analysis. Objectives To compare the efficacy and safety of bone marrow
(BM)–derived mesenchymal stem cell (MSCs) and adipose-derived (AD) MSCs in the …

Safety and efficacy of adipose-derived mesenchymal stem cells for knee osteoarthritis: a systematic review and m-analysis

M Gadelkarim, A Abd Elmegeed, AH Allam, AK Awad… - Joint Bone Spine, 2022 - Elsevier
Objective This research aimed to study the safety and efficacy of adipose-derived
mesenchymal stem cells (ADMSCs) for knee osteoarthritis (OA). Methods We used six …

Mesenchymal stromal cells in osteoarthritis: evidence for structural benefit and cartilage repair

Y Song, C Jorgensen - Biomedicines, 2022 - mdpi.com
Osteoarthritis (OA) presents a major clinical challenge to rheumatologists and orthopedists
due to the lack of available drugs reducing structural degradation. Mesenchymal stromal …

[PDF][PDF] Controversies in regenerative medicine: Should knee joint osteoarthritis be treated with mesenchymal stromal cells

R Ossendorff, SG Walter, FA Schildberg, M Khoury… - Eur Cell …, 2022 - researchgate.net
Knee joint osteoarthritis is a complex immunological and degenerative disease. Current
treatment strategies fail to alter its progression. Mesenchymal stromal cell (MSC) therapy for …

Application of tissue-derived bioink for articular cartilage lesion repair

J Wu, Y Han, Q Fu, Y Hong, L Li, J Cao, H Li… - Chemical Engineering …, 2022 - Elsevier
Articular cartilage (AC) lesions are common but remain a great challenge for researchers
and clinicians mainly due to their poor self-healing capability. Decellularized cartilage …

Cell and cell free therapies in osteoarthritis

P Peláez, E Damiá, M Torres-Torrillas, D Chicharro… - Biomedicines, 2021 - mdpi.com
Osteoarthritis (OA) is the most common articular disease in adults and has a current
prevalence of 12% in the population over 65 years old. This chronic disease causes …

Basic science of autologous orthobiologics: part 2. Mesenchymal stem cells

PA Everts, AJ Panero - Physical Medicine and Rehabilitation …, 2023 - pmr.theclinics.com
The objectives of regenerative medicine applications are to support the body to form new
functional tissues to replace degenerative or defective ones and to provide therapeutic …

Evolution of hydrogels for cartilage tissue engineering of the knee: A systematic review and meta-analysis of clinical studies

SA Hosseini, R Mohammadi, S Noruzi, R Ganji… - Joint bone spine, 2021 - Elsevier
Introduction In recent years, studies have boosted our knowledge about the biology and
disorders of articular cartilage. In this regard, the design of hydrogel-based scaffolds has …